杜宏武
- 办公地点： 大兴区永大路41号院
- 办公电话： 61252260
- 电子邮件： hongwudu@ustb.edu.cn
- 本科课程： 《现代生物技导论》、《生物芯片》
- 研究生课程： 《干细胞制药》
- 科研方向： 生物芯片、生物制药、干细胞临床应用
- 社会职务：首都干细胞公共平台主任
2006年12月北京科技大学“321”人才引进我校原应用学院，现任化生学院教授、博士生导师。自2020年12月受聘执行院长负责组建北科大兴研究院。其中2009年5月至2011年8月，受聘美国斯坦福大学医学院，国际人类免疫监测计划高通量数据分析专家。
博士：清华大学，医学院，系统生物学研究中心。
硕士：中国协和医科大学/中国医学科学院。
本科：山东大学，生命科学学院。
长期致力高通量生物技术的生物制药转化研究，培养优秀博士/硕士/本科毕业生超过百名，毕业去向包括出国留学哈佛、耶鲁、斯坦福、牛津、剑桥、帝国理工等；国内就业包括国家级科研机构、高等院校和知名上市公司等。主持国家级基金数十项，开发上市多种产品，如世界第一个兴奋剂检测蛋白芯片、世界第一个自身免疫病检测芯片、中国第一个GAD检测试剂等，获国家新药证书及医疗器械许可证16件，转化形成高科技生物医药产品300余种，服务多家上市企业。
国际奥委会“反兴奋剂科研试剂第一名”
美国“HIMC 杰出贡献奖”
国家“科技奥运先进个人”
教育部“新世纪优秀人才”
江苏省“双创人才”
中关村“新国门领军人才”
教育部“宝钢优秀教师奖”。
硕士、博士、博士后
1. Advances in mesenchymal stromal cells and nanomaterials for diabetic wound healing.Hou L, Zhang X, Du H. Diabetes Metab Res Rev. 2023 Mar 23:e3638. doi: 10.1002/dmrr.3638.
2. Potential application of heat shock proteins as therapeutic targets in Parkinson's disease. Guo H, Yi J, Wang F, Lei T, Du H. Neurochem Int. 2023 Jan;162:105453. doi: 10.1016/j.neuint.2022.105453. Epub 2022 Nov 17.
3. Induction of autophagy via the PI3K/Akt/mTOR signaling pathway by Pueraria flavonoids improves non-alcoholic fatty liver disease in obese mice. Sun C, Zhang J, Hou J, Hui M, Qi H, Lei T, Zhang X, Zhao L, Du H. Biomed Pharmacother. 2023 Jan;157:114005. doi: 10.1016/j.biopha.2022.114005. Epub 2022 Nov 13.
4. Regulatory factor identification for nodal genes in zebrafish by causal inference. Xing C, Zeng Z, Li Y, Gong B, Shen W, Shah R, Yan L, Du H, Meng A. Front Cell Dev Biol. 2022 Oct 20;10:1047363. doi: 10.3389/fcell.2022.1047363. eCollection 2022.
5. Potential of astrocytes in targeting therapy for Alzheimer's disease. Bi W, Lei T, Cai S, Zhang X, Yang Y, Xiao Z, Wang L, Du H. Int Immunopharmacol. 2022 Dec;113(Pt A):109368. doi: 10.1016/j.intimp.2022.109368. Epub 2022 Oct 29.
6. Intestinal Flora Affect Alzheimer's Disease by Regulating Endogenous Hormones. Wu Y, Hang Z, Lei T, Du H. Neurochem Res. 2022 Dec;47(12):3565-3582. doi: 10.1007/s11064-022-03784-w. Epub 2022 Oct 30.
7. Targeting small heat shock proteins to degrade aggregates as a potential strategy in neurodegenerative diseases. Lei T, Xiao Z, Bi W, Cai S, Yang Y, Du H. Ageing Res Rev. 2022 Dec;82:101769. doi: 10.1016/j.arr.2022.101769. Epub 2022 Oct 22.
8. Metformin pre-treatment of stem cells from human exfoliated deciduous teeth promotes migration and angiogenesis of human umbilical vein endothelial cells for tissue engineering. Deng S, Lei T, Chen H, Zheng H, Xiao Z, Cai S, Hang Z, Xiong W, Yu Y, Zhang X, Yang Y, Bi W, Du H. Cytotherapy. 2022 Nov;24(11):1095-1104. doi: 10.1016/j.jcyt.2022.07.003. Epub 2022 Sep 5.
9. Human gingival mesenchymal stem cells improve movement disorders and tyrosine hydroxylase neuronal damage in Parkinson disease rats. Lei T, Xiao Z, Zhang X, Cai S, Bi W, Yang Y, Wang D, Li Q, Du H. Cytotherapy. 2022 Nov;24(11):1105-1120. doi: 10.1016/j.jcyt.2022.06.007. Epub 2022 Aug 13.
10. Inflammatory bowel disease: A potential pathogenic factor of Alzheimer's disease. Wang D, Zhang X, Du H. Prog Neuropsychopharmacol Biol Psychiatry. 2022 Dec 20;119:110610. doi: 10.1016/j.pnpbp.2022.110610. Epub 2022 Jul 28.
11. A porphyrin-triazatruxene dyad for ratiometric two-photon fluorescent sensing of intracellular viscosity. Wang Y, Lei T, Zhang J, Gong L, Yang Y, Ma X, Wen Y, Du H, Qi D, Bian Y, Liu Z, Jiang J. J Mater Chem B. 2022 Jul 20;10(28):5487-5492. doi: 10.1039/d2tb00384h.
12. Stem cells from human exfoliated deciduous teeth relieves Alzheimer's disease symptoms in SAMP8 mice by up-regulating the PPARγ pathway. Zhang X, Lei T, Wang D, Cai S, Hang Z, Yang Y, Bi W, Xiao Z, Du H. Biomed Pharmacother. 2022 Aug;152:113169. doi: 10.1016/j.biopha.2022.113169. Epub 2022 Jun 9.
13. The combined therapy of mesenchymal stem cell transplantation and resveratrol for diabetes: Future applications and challenges. Yang Y, Lei T, Bi W, Xiao Z, Zhang X, Du H. Life Sci. 2022 Jul 15;301:120563. doi: 10.1016/j.lfs.2022.120563. Epub 2022 Apr 20.
14. Hydrogel supplemented with human platelet lysate enhances multi-lineage differentiation of mesenchymal stem cells. Lei T, Liu Y, Deng S, Xiao Z, Yang Y, Zhang X, Bi W, Du H. Nanobiotechnology. 2022 Apr 2;20(1):176. doi: 10.1186/s12951-022-01387-9.
15. Chitosan Hydrogel Supplemented with Metformin Promotes Neuron-like Cell Differentiation of Gingival Mesenchymal Stem Cells. Cai S, Lei T, Bi W, Sun S, Deng S, Zhang X, Yang Y, Xiao Z, Du H. Int J Mol Sci. 2022 Mar 18;23(6):3276. doi: 10.3390/ijms23063276.
16. Comparative proteomics analysis of human stem cells from dental gingival and periodontal ligament. Lei T, Wang J, Liu Y, Zhang X,Du H. Proteomics. 2022 Jun;22(11-12):e2200027. doi: 10.1002/pmic.202200027. Epub 2022 Mar 30.
17. Transplantation of feces from mice with Alzheimer's disease promoted lung cancer growth. Bi W, Cai S, Hang Z, Lei T, Wang D, Wang L, Du H. Biochem Biophys Res Commun. 2022 Apr 16;600:67-74. doi: 10.1016/j.bbrc.2022.01.078. Epub 2022 Jan 24.
18. Transfer of Tumor-Bearing Mice Intestinal Flora Can Ameliorate Cognition in Alzheimer's Disease Mice. Hang Z, Cai S, Lei T, Zhang X, Xiao Z, Wang D, Li Y, Bi W, Yang Y, Deng S, Wang L, Li Q, Du H. J Alzheimers Dis. 2022;86(3):1287-1300. doi: 10.3233/JAD-215495.
19. Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer. Hang Z, Lei T, Zeng Z, Cai S, Bi W, Du H. Biomed Pharmacother. 2022 Jan;145:112343. doi: 10.1016/j.biopha.2021.112343. Epub 2021 Dec 1.
20. Stem Cells from Human Exfoliated Deciduous teeth Promote Hair Regeneration in Mouse. Zhang X, Lei T, Chen P, Wang L, Wang J, Wang D, Guo W, Zhou Y, Li Q, Du H. Cell Transplant. 2021 Jan-Dec;30:9636897211042927. doi: 10.1177/09636897211042927.
21. Stem cells from human exfoliated deciduous teeth affect mitochondria and reverse cognitive decline in a senescence-accelerated mouse prone 8 model. Guo W, Zeng Z, Xing C, Zhang J, Bi W, Yang J, Shah R, Wang D, Li Y, Zhang X, Bian Y, Du H. Cytotherapy. 2022 Jan;24(1):59-71. doi: 10.1016/j.jcyt.2021.07.018. Epub 2021 Sep 29.
22. Metformin enhances the osteogenesis and angiogenesis of human umbilical cord mesenchymal stem cells for tissue regeneration engineering. Lei T, Deng S, Chen P, Xiao Z, Cai S, Hang Z, Yang Y, Zhang X, Li Q, Du H. Int J Biochem Cell Biol. 2021 Dec;141:106086. doi: 10.1016/j.biocel.2021.106086. Epub 2021 Sep 20.
23. Prospect of cell penetrating peptides in stem cell tracking. Zhang X, Lei T, Du H. Stem Cell Res Ther. 2021 Aug 14;12(1):457. doi: 10.1186/s13287-021-02522-3.
24. Lei T, Deng S, Chen P, Xiao Z, Cai S, Hang Z, Yang Y, Zhang X, Li Q, Du H. Metformin enhances the osteogenesis and angiogenesis of human umbilical cord mesenchymal stem cells for tissue regeneration engineering. Int J Biochem Cell Biol. 2021 Sep 19:106086. doi: 10.1016/j.biocel.2021.106086.
25. Zhang X, Lei T, Du H. Prospect of cell penetrating peptides in stem cell tracking. Stem Cell Res Ther. 2021 Aug 14;12(1):457. doi: 10.1186/s13287-021-02522-3.
26. Lei T, Zhang X, Du H. Characteristics, Classification, and Application of Stem Cells Derived from Human Teeth. Stem Cells Int. 2021 May 31;2021:8886854. doi: 10.1155/2021/8886854.
27. WenhuanGuo, ZehuaZeng, CencanXing, et al, Du H. Stem cells from human exfoliated deciduous teeth affect Mitochondria and reverse cognitive decline in a senescence accelerated mouse (SAMP8) model. Cytotheraphy. 2021 accepted.
28. Lei T, Wang J, Liu Y, Chen P, Zhang Z, Zhang X, Guo W, Wang X, Li Q, Du H. Proteomic profile of human stem cells from dental pulp and periodontal ligament. J Proteomics. 2021 Aug 15;245:104280. doi: 10.1016/j.jprot.2021.104280.
29. XiaoshuangZhang, Tong Lei, Peng Chen, et al., Du H. Stem cells from human exfoliated deciduous teeth promote hair regeneration in mouse. Cell Transplantation. 2021 accepted.
30. Lei T, Wang J, Liu Y, Chen P, Zhang Z, Zhang X, Wang X, Li Q, Du H. Calreticulin as a special marker to distinguish dental pulp stem cells from gingival mesenchymal stem cells. Int J Biol Macromol. 2021 May 1;178:229-239. doi: 10.1016/j.ijbiomac.2021.02.126.
31. Xiao Z, Lei T, Liu Y, Yang Y, Bi W, Du H. The potential therapy with dental tissue-derived mesenchymal stem cells in Parkinson's disease. Stem Cell Res Ther. 2021 Jan 6;12(1):5. doi: 10.1186/s13287-020-01957-4.
32. Zeng Z, Xiong Y, Guo W, Du H. ERgene: Python library for screening endogenous reference genes. Sci Rep. 2020 Oct 29;10(1):18557. doi: 10.1038/s41598-020-75586-5.
33. Wang L, Du H, Chen P. Chlorogenic acid inhibits the proliferation of human lung cancer A549 cell lines by targeting annexin A2 in vitro and in vivo. Biomed Pharmacother. 2020 Nov;131:110673. doi: 10.1016/j.biopha.2020.110673.
34. ZehuaZeng, ZhiLuo, Du H. Predictions for the binding domain and potential new drug targets of 2019-nCoVdoi.org/10.1101/2020.02.961938.
35. Chen P, Zeng Z, Du H. Establishment and validation of a drug-target microarray for SARS-CoV-2. Biochem Biophys Res Commun. 2020 Sep 10;530(1):4-9. doi: 10.1016/j.bbrc.2020.05.217.
36. Lei T, Zhang X, Chen P, Li Q, Du H. Proteomic profile of human dental follicle stem cells and apical papilla stem cells. J Proteomics. 2021 Jan 16;231:103928. doi: 10.1016/j.jprot.2020.103928.
37. MengmengShi, QingyuanYang, AntoineMonsel, JiayangYan, ChenxiangDai, Du H. etal. Preclinical efficacy and clinical safety of clinical-grade nebulized allogenic adipose mesenchymal stromal cells-derived extracellular vesicles. J ExtracellVesicles. 2021 Aug;10(10):e12134. doi: 10.1002/jev2.12134.
38. Chen P, Wang L, Sun S, Zhou Q, Zeng Z, Hu M, Hussain M, Lu C, Du H. High-throughput screening suggests glutathione synthetase as an anti-tumor target of polydatin using human proteome chip. Int J Biol Macromol. 2020 Oct 15;161:1230-1239. doi: 10.1016/j.ijbiomac.2020.06.061.
39. ZehuaZeng, ZhiLuo, YubangShan, etal., Du H. The unignorableN protein of COVID-192020 June. doi:10.21203/rs.3.rs-34518/v1.
40. Hussain M, Chen P, Zhang Y, Tian Y, Du H. Moesin expression is correlated with its involvement in patients with Behcet's disease. Arch Med Sci. 2020 Feb 12;16(4):924-930. doi: 10.5114/aoms.2020.92911. eCollection 2020.
41. Zhang J, Gong L, Zhang X, Zhu M, Su C, Ma Q, Qi D, Bian Y, Du H, Jiang J. Multipolar Porphyrin-Triazatruxene Arrays for Two-Photon Fluorescence Cell Imaging. Chemistry. 2020 Nov 2;26(61):13842-13848. doi: 10.1002/chem.202001367.
42. Hussain M, Ma F, Chen P, Tian Y, Du H. Circulation autoantibodies against C-terminus of NuMA in patients with Behçet's disease. Cent Eur J Immunol. 2020;45(1):86-92. doi: 10.5114/ceji.2020.94710.
43. Zhou Y, Cui J, Hu H, Wen Y, Du Z, Du H. Identification of a novel anti‑heat shock cognate 71 kDa protein antibody in patients with Kawasaki disease. Mol Med Rep. 2020 Apr;21(4):1771-1778. doi: 10.3892/mmr.2020.10973.
毕业学生去向包括国外大学（哈佛、斯坦福、UCLA、帝国理工）；国内高校任教；生物医药上市公司；中央驻京科研单位
