简    历

幸岑璨，北京科技大学学士，清华大学理学博士，长期围绕细胞发育基础特性，并采用多组学等现代生物信息学算法，解决干细胞多靶点治疗衰老及退行性疾病等复杂分子作用机理；主持和参加国家自然科学基金、国家重点研发专项子课题、北京市科技新星交叉项目、中央高校基本科研业务费、青年教师学科交叉研究项目、中国国检集团生物安全评价开发等项目10余项，申请国家发明专利10余项，在Cell、Nat Commun、EMBO J、Adv Funct Mater等国际知名期刊发表SCI论文30余篇。

科研业绩

1. 北京市科技新星交叉项目，2026年，主持

2. 青年教师学科交叉研究项目，2025年，主持

3. 国家自然科学基金青年项目，2023年，主持

4. 中国国检集团生物安全评价方法开发，2022年，主持

5. 国家重点研发专项子课题，2022年，主持

6. 中央高校基本科研业务费，2022年，主持

7. 国家重点研发专项子课题，2019年，主持

获得奖励/专利

代表性奖励：

国家级学生竞赛优秀指导教师、中国国际大学生创新大赛一等奖及二等奖指导老师、北京市优秀毕业生（本科及博士毕业两次）、清华优秀博士毕业论文、北京市清华大学-北京大学生命科学联合中心（CLS）优秀博士后基金、博士研究生国家奖学金、国家特等奖学金（本科期间，两次）

专利：

授权国家发明专利10余项

代表性论文著作

[1]Nebulized delivery of multi-modular stem cell-derived exosomes for the treatment of pulmonary fibrosis. Gao X#, Sun C#, Yang Y#, Li L, Sha S, Cai S, Li L, Hang Z, Wang L*, Xing C*, Du H*. Nanomedicine. 2026 Jun;74:102925. doi: 10.1016/j.nano.2026.102925. Epub 2026 Mar 6.

[2]ROS-Responsive Hybrid Nanoparticles Enable Dual-Target Neurovascular Repair via Blood-Brain Barrier-on-Chip Validation. Cai S, Bi W, Li L, Gao X, Sun C, Hang Z, Chen H, Li Y, Xing C*, Wang L*, Du H*. Small. 2026 Jan;22(6):e07595. doi: 10.1002/smll.202507595. Epub 2026 Jan 9.

[3]CellOntologyMapper: Consensus mapping of cell type annotation. Zeng Z, Wang X, Du H*, Xing C*. iMetaomics, 3: e70064 (2025)

[4]Integrated Microfluidic Hydrogel-Enhanced Microwell Array for Uniform Self-Assembly, Long-Term Culture, and Neural Differentiation of Mesenchymal Stem Cell Spheroids. Bi W, Cai S, Zhou L, Zheng J, Cui Y, Li Y, Liu S, Chen H, Sha S, Li J, Ma Q, Bao Z, Xing C*, Wang L*, Du H*. Adv Funct Materials. 2025, 2501265.

[5]Engineered Stem Cell Membrane-Coated Nanodrugs for Targeted Therapy of Alzheimer's Disease. Sha S#, Sun C#, Gao X, Bi W, Chen H, Ren W, Wang L, Luo E*, Xing C*, Du H*. ACS Appl Mater Interfaces. 2025 Aug 20;17(33):47497-47511. doi: 10.1021/acsami.5c09843. Epub 2025 Aug 6.

[6]Injectable polypeptide/chitosan hydrogel with loaded stem cells and rapid gelation promoting angiogenesis for diabetic wound healing. Xing C#, Hou L#, Sun C#, Chen H, Li Y, Li L, Wu Y, Li L, An H*, Wen Y*, Du H*. Int J Biol Macromol., 2025 May;306(Pt 2):141578.

[7]Biomimetic Nanoparticles Enhance Recovery of Movement Disorders in Parkinson's Disease by Improving Microglial Mitochondrial Homeostasis and Suppressing Neuroinflammation. Li L, Sun C, Cai S, Hang Z, Gao X, Hou L, Li L, Wu Y, Xing C*, Du H*. ACS Appl Mater Interfaces. 2025 Apr 23;17(16):23536-23552.

[8]scLTNN: an innovative tool for automatically visualizing single-cell trajectories. Xing C#, Zeng Z#, Hu L, Kang J, Roshan S, Xiong Y*, Du H*, Zhao T*. Bioinform Adv., 2025 Feb 26;5(1):vbaf033.

[9]Neuroprotective effects of mesenchymal stromal cells in mouse models of Alzheimer's Disease: The Mediating role of gut microbes and their metabolites via the Microbiome-Gut-Brain axis. Xing C#, Zhang X#, Wang D, Chen H, Gao X, Sun C, Guo W, Roshan S, Li Y, Hang Z, Cai S, Lei T, Bi W, Hou L, Li L, Wu Y, Li L, Zeng Z*, Du H*. Brain Behav Immun. 2024 Nov;122:510-526. doi: 10.1016/j.bbi.2024.08.047.

[10]OmicVerse: a framework for bridging and deepening insights across bulk and single-cell sequencing. Zeng Z, Ma Y, Hu L, Tan B, Liu P, Wang Y, Xing C*, Xiong Y*, Du H*. Nat Commun. 2024 Jul 16;15(1):5983. doi: 10.1038/s41467-024-50194-3.

[11]Stem cells from human exfoliated deciduous teeth rejuvenate the liver in naturally aged mice by improving ribosomal and mitochondrial proteins. Xing C#, Hang Z#, Guo W#, Li Y, Shah R, Zhao Y, Zeng Z, Du H. Cytotherapy. 2023 Dec;25(12):1285-1292. doi: 10.1016/j.jcyt.2023.08.015.

[12]A Network Pharmacology-based Study on the Anti-aging Properties of Traditional Chinese Medicine Sisheng Bulao Elixir. Xing C#, Zeng Z#, Shan Y, Guo W, Shah R, Wang L, Wang Y*, Du H*. Comb Chem High Throughput Screen. 2024;27(12):1840-1849. doi: 10.2174/0113862073276253231114063813.

[13]Comprehensive maturity of nuclear pore complexes regulates zygotic genome activation. Shen W, Gong B, Xing C, Zhang L, Sun J, Chen Y, Yang C, Yan L, Chen L, Yao L, Li G, Deng H, Wu X, Meng A*. Cell. 2022 Dec 22;185(26):4954-4970.e20. doi: 10.1016/j.cell.2022.11.011.

[14]Maternal Factors and Nodal Autoregulation Orchestrate Nodal Gene Expression for Embryonic Mesendoderm Induction in the Zebrafish. Xing C, Shen W, Gong B, Li Y, Yan L, Meng A*. Front Cell Dev Biol. 2022 May 26;10:887987. doi: 10.3389/fcell.2022.887987.

[15]Stem cells from human exfoliated deciduous teeth affect mitochondria and reverse cognitive decline in a senescence-accelerated mouse prone 8 model. Guo W#, Zeng Z#, Xing C#, Zhang J, Bi W, Yang J, Shah R, Wang D, Li Y, Zhang X, Bian Y*, Du H*. Cytotherapy. 2022 Jan;24(1):59-71. doi: 10.1016/j.jcyt.2021.07.018. Epub 2021 Sep 29.

[16]A zebrafish (danio rerio) model for high-throughput screening food and drugs with uric acid-lowering activity. Zhang Y, Li Q, Wang F*, Xing C*. Biochem Biophys Res Commun. 2019 Jan 8;508(2):494-498. doi: 10.1016/j.bbrc.2018.11.050.

[17]Tgfβ1a Regulates Zebrafish Posterior Lateral Line Formation via Smad5 Mediated Pathway. Xing C, Gong B, Xue Y, Han Y, Wang Y, Meng A*, Jia S*. J Mol Cell Biol. 2015 Feb;7(1):48-61. doi: 10.1093/jmcb/mjv004.

[18]SCFFBXL15 regulates BMP signaling by directing the degradation of HECT-type ubiquitin ligase Smurf1. Cui Y#, He S#, Xing C#, Lu K, Wang J, Xing G, Meng A, Jia S*, He F*, Zhang L*. EMBO J. 2011 May 13;30(13):2675-89. doi: 10.1038/emboj.2011.155.

研究生培养情况

目前在读硕士研究生2人，已毕业硕士研究生1人；协助指导博士研究生3人、硕士研究生3人，协助指导硕士研究生已毕业2人（其中1人获得北京科技大学优秀毕业论文）

招生计划

每年1-2名硕士